HEMATOBIOCHEMICAL EFFECTS OF TELAKUCHA (Coccinia indica) IN ALLOXAN INDUCED DIABETIC RATS

Abstract

The study was undertaken to investigate the effects of Telakucha (Coccinia indica) on blood glucose, serum total cholesterol, hematological parameters and body weight on alloxan induced diabetic rats. Forty five rats were divided into 3 equal groups: Control (C), Diabetic Control (DC) and Diabetic Treatment (DT). DT group was treated with 10% aqueous extract of Telakucha 500 mg/kg body weight. Telakucha extract reduced the amount of blood glucose significantly (P<0.001) in the group DT compared to DC from 32.03 ± 0.25 to 11.17 ± 0.08 mmol/L. Total cholesterol (TC) was decreased significantly (P<0.001) in group DT compared to group DC from 121.85 ±0.27 to 112.42±0.14 mg/dL. In hematological study, DT group showed significant (P<0.001) increase of erythrocytes count & Hb (g%) content and decrease (P<0.001) of total leukocyte count after 42 days of treatment in contrast with DC group. The body weight was also increased significantly (P<0.001) in DT group. Based on present research it can be concluded that Telakucha can be used in the treatment of diabetes as an alternative to commercial medicine.