Abstract:
The study was conducted on “Swiss Albino” mice (Mus musculus) fed with additional
supplementation of rice bran oil, soybean oil and palm oil to observe their effects on
biochemical parameters (total ser um cholesterol, triglycerides, high densi t y lipoproteins
and creatinine). A total of 40 (4-5weeks old) mice were randomly divided into 4 equal groups
(n=10) as A, B, C and D. Group A was considered as control, fed only commercial ration and
other groups were supplemented with rice bran oil (group B), soybean oil (group C) and palm oil
(group D) respectively in addition to commercial ration for 60 days. The serum total cholesterol
in oil treated groups differed significantly (p<0.05) from control group (95.43 ± 2.16 mg/dl)
and was highest in palm oil group (131.468 ± 2.6 mg/dl) among the oil treated groups. The
triglycerides in palm oil (172.32 ± 3.09 mg/dl) treated group varied significantly (p<0.05) from
control (150.79 ± 3.95 mg/dl) and other oil treated groups. The serum creatinine in palm oil
(1.15 ± 0.96 mg/dl) treated group also varied significantly (p<0.05) from control (0.69 ± 0.04
mg/dl) and other oil treated groups. The high density lipoprotein (HDL) in soybean oil treated
group (79.48 ± 5.87) differed significantly (p<0.05) from palm oil (63.72 ± 6.81) and control
groups (54.47 ± 4.54) but close to rice bran oil group (73.19 ± 3.96). Further investigation is
necessary with large number of animals and addition of more parameters like liver function,
kidney function which will give more precise information about the effect of these oils.
